1+ months

Musculoskeletal - Postdoctoral Researcher

Lawrence Livermore National Laboratory
Livermore, CA 94550

NOTE: This is a two-year term appointment with the possibility of extension to a maximum of three years.

We are seeking a Postdoctoral Researcher to work in the area of musculoskeletal biology. You will actively study the effect of trauma on bones and joints, with the aim of identifying therapeutic approaches that prevent the development of post traumatic osteoarthritis. This position is in the Human and Health Sciences group in the Biosciences and Biotechnology Division.

In this role you will

  • Conduct research in the field of musculoskeletal biology, exploring biomechanics of bone and cartilage, characterizing the molecular changes (transcriptional/proteomic) of the injured joint to understand how post-traumatic osteoarthritis develops.
  • Design, implement, and analyze experiments for the characterization of bone-cartilage interaction, use spatial transcriptomics/proteomics to quantify cartilage and bone metabolism and turnover.
  • Evaluate potential cell based and pharmaceutical therapies for the prevention of post traumatic osteoarthritis.
  • Organize, analyze, and present data from research at seminars, technical meetings, national and international conferences.
  • Contribute to and actively participate in the conception, design, and execution of research to address defined problems.
  • Pursue independent (but complementary) research interests and interact with a broad spectrum of scientists internally and externally to the Laboratory.
  • Collaborate with others in a multidisciplinary team environment and other national laboratories and industry to accomplish research goals.
  • Publish research results in peer-reviewed scientific or technical journals and present results at external conferences seminars and/or technical meetings.
  • Perform other duties as assigned.

  • PhD in Systems Biology, Molecular and Cell Biology, Genetics or Quantitative Biology or related field, with emphasis in musculoskeletal biology, bone disease or post-traumatic osteoarthritis.
  • Experience with one or more of the following areas: animal models of disease, in vivo imaging and phenotyping animals with genetic modifications.
  • Experience with histology, molecular biology, delivering drugs and reagents to animal models, isolating tissues, processing tissues.
  • Experience performing bulk and scRNA sequencing and analysis
  • Experience with cell sorting, immunohistochemistry, purifying cell sub-populations from tissues
  • Ability to manage and perform large scale experiments
  • Proficient verbal and written communication and interpersonal skills to collaborate effectively in a multidisciplinary team environment and present and explain technical information.

Qualifications we desire

  • Experience with surgical and non-invasive animal models of post-traumatic osteoarthritis.
  • Experience with cellular and tissue culture.
  • Experience with RNA sequencing and analysis and with cell sorting, immunohistochemistry, immune profiling.

Why Lawrence Livermore National Laboratory?

  • Included in 2022 Best Places to Work by Glassdoor!
  • Work for a premier innovative national Laboratory
  • Comprehensive Benefits Package
  • Flexible schedules (*depending on project needs)
  • Collaborative, creative, inclusive, and fun team environment

Learn more about our company, selection process, position types and security clearances by visiting our Career site.

COVID-19 Vaccination Mandate

LLNL demonstrates its commitment to public safety by requiring that all new Laboratory employees be immunized against COVID-19 unless granted an accommodation under applicable state or federal law. This requirement will apply to all new hires including those who will be working on site, as well as those who will be teleworking.

Security Clearance

LLNL is a Department of Energy (DOE) and National Nuclear Security Administration (NNSA) Laboratory. Most positions will require a DOE L or Q clearance (please reference Security Clearance requirement). If you are selected, we will initiate a Federal background investigation to determine if you meet eligibility requirements for access to classified information or matter. In addition, all L or Q cleared employees are subject to random drug testing. An L or Q clearance requires U.S. citizenship. If you hold multiple citizenships (U.S. and another country), you may be required to renounce your non-U.S. citizenship before a DOE L or Q clearance will be processed/granted. For additional information please see DOE Order 472.2.

Equal Employment Opportunity

LLNL is an affirmative action and equal opportunity employer that values and hires a diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

If you need assistance and/or a reasonable accommodation during the application or the recruiting process, please submit a request via our online form.

California Privacy Notice

The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.

Position Information

This is a Postdoctoral appointment with the possibility of extension to a maximum of three years. Eligible candidates are those who have been awarded a PhD at time of hire date.

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Why Lawrence Livermore National Laboratory?

  • Included in 2022 Best Places to Work by Glassdoor!
  • Work for a premier innovative national Laboratory
  • Comprehensive Benefits Package
  • Flexible schedules (*depending on project needs)
  • Collaborative, creative, inclusive, and fun team environment

Learn more about our company, selection process, position types and security clearances by visiting our Career site.

\n

COVID-19 Vaccination Mandate

LLNL demonstrates its commitment to public safety by requiring that all new Laboratory employees be immunized against COVID-19 unless granted an accommodation under applicable state or federal law. This requirement will apply to all new hires including those who will be working on site, as well as those who will be teleworking.

\n

Security Clearance

None required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check. (This process does not apply to foreign nationals.) For additional information, please see DOE Order 472.2.

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Pre-Employment Drug Test

External applicant(s) selected for this position will be required to pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

\n

Pre-Placement Medical Exam

A job related pre-placement medical examination may be required.

\n

Equal Employment Opportunity

LLNL is an affirmative action and equal opportunity employer that values and hires a diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

If you need assistance and/or a reasonable accommodation during the application or the recruiting process, please submit a request via our online form.

\n

California Privacy Notice

The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.


Join us and make YOUR mark on the World!

Are you interested in joining some of the brightest talent in the world to strengthen the United States' security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.

We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory's mission.

"},"jobDescription":{"title":"Job Description","text":"

NOTE: This is a two-year term appointment with the possibility of extension to a maximum of three years.

We are seeking a Postdoctoral Researcher to work in the area of musculoskeletal biology. You will actively study the effect of trauma on bones and joints, with the aim of identifying therapeutic approaches that prevent the development of post traumatic osteoarthritis. This position is in the Human and Health Sciences group in the Biosciences and Biotechnology Division.

In this role you will

  • Conduct research in the field of musculoskeletal biology, exploring biomechanics of bone and cartilage, characterizing the molecular changes (transcriptional/proteomic) of the injured joint to understand how post-traumatic osteoarthritis develops.
  • Design, implement, and analyze experiments for the characterization of bone-cartilage interaction, use spatial transcriptomics/proteomics to quantify cartilage and bone metabolism and turnover.
  • Evaluate potential cell based and pharmaceutical therapies for the prevention of post traumatic osteoarthritis.
  • Organize, analyze, and present data from research at seminars, technical meetings, national and international conferences.
  • Contribute to and actively participate in the conception, design, and execution of research to address defined problems.
  • Pursue independent (but complementary) research interests and interact with a broad spectrum of scientists internally and externally to the Laboratory.
  • Collaborate with others in a multidisciplinary team environment and other national laboratories and industry to accomplish research goals.
  • Publish research results in peer-reviewed scientific or technical journals and present results at external conferences seminars and/or technical meetings.
  • Perform other duties as assigned.
"},"qualifications":{"title":"Qualifications","text":"
  • PhD in Systems Biology, Molecular and Cell Biology, Genetics or Quantitative Biology or related field, with emphasis in musculoskeletal biology, bone disease or post-traumatic osteoarthritis.
  • Experience with one or more of the following areas: animal models of disease, in vivo imaging and phenotyping animals with genetic modifications.
  • Experience with histology, molecular biology, delivering drugs and reagents to animal models, isolating tissues, processing tissues.
  • Experience performing bulk and scRNA sequencing and analysis
  • Experience with cell sorting, immunohistochemistry, purifying cell sub-populations from tissues
  • Ability to manage and perform large scale experiments
  • Proficient verbal and written communication and interpersonal skills to collaborate effectively in a multidisciplinary team environment and present and explain technical information.

Qualifications we desire

  • Experience with surgical and non-invasive animal models of post-traumatic osteoarthritis.
  • Experience with cellular and tissue culture.
  • Experience with RNA sequencing and analysis and with cell sorting, immunohistochemistry, immune profiling.

Categories

Posted: 2022-04-08 Expires: 2022-06-09

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Musculoskeletal - Postdoctoral Researcher

Lawrence Livermore National Laboratory
Livermore, CA 94550

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